WebApr 12, 2012 · In addition to chromosome dimer resolution and based on the absence of genes for topoisomerase IV ( parC, parE) in H. pylori, we speculate that XerH may contribute to chromosome decatenation, although possible involvement of H. pylori 's DNA gyrase and topoisomerase III homologue are also considered. WebApr 14, 1998 · Purified ParE and ParC proteins reconstituted to form topoisomerase IV (topo IV), which was highly proficient for ATP-dependent superhelical DNA relaxation …
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative ...
WebFeb 1, 2009 · The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazolo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported.The most potent scaffold was selected for optimization leading to … WebAug 20, 2024 · In this review, we focused on the importance of unexploited enzyme, ParE, a topoisomerase responsible for the bacterial survival. The bacterial topoisomerases maintain the topological state of DNA. mayor eddie moran office
Design and synthesis of peptides from bacterial ParE …
WebBacterial topoisomerase IV is also an A 2 B 2 tetramer comprised of two subunits. In Gram-negative species, these subunits were first identified as proteins required for chromosomal partitioning. They are designated ParC (molecular mass ≈ 88 kDa) and ParE (molecular mass ≈ 70 kDa), which are homologous to the A and B subunits of DNA gyrase. WebApr 1, 2024 · This compound has been investigated further on methicillin-resistant S. aureus (MRSA) and on ciprofloxacin non-susceptible and extremely drug resistant strain of S. aureus (MRSA VISA). It exhibited the MIC value of 2.5 μM on both strains, and MIC value of 32 μM against MRSA in the presence of inactivated human blood serum. Type II topoisomerases are topoisomerases that cut both strands of the DNA helix simultaneously in order to manage DNA tangles and supercoils. They use the hydrolysis of ATP, unlike Type I topoisomerase. In this process, these enzymes change the linking number of circular DNA by ±2. … See more Type II topoisomerases increase or decrease the linking number of a DNA loop by 2 units, and it promotes chromosome disentanglement. For example, DNA gyrase, a type II topoisomerase … See more There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes See more Strand passage Type IIA topoisomerase operates through a "two-gate" mechanism (though this is a historical notation), a mechanism supported by … See more Small molecules that target type II topoisomerase are divided into two classes: inhibitors and poisons. Due to their frequent … See more Type IIA topoisomerases are essential in the separation of entangled daughter strands during replication. This function is believed to be performed by topoisomerase II in eukaryotes and by topoisomerase IV in prokaryotes. Failure to separate these … See more Type IIA Type IIA topoisomerases consist of several key motifs: • an … See more Catenation is the process by which two circular DNA strands are linked together like chain links. This occurs after DNA replication, where two single strands are catenated and can … See more hervé hocquard teaching