Hepatokine
WebNov 22, 2024 · HGFAC is a ChREBP-regulated hepatokine that enhances glucose and lipid homeostasis Ashot Sargsyan, 1 Ludivine Doridot, 2 Sarah A. Hannou, 1 Wenxin Tong, 1 Harini Srinivasan, 2,3 Rachael Ivison, 2 Ruby Monn, 1 Henry H. Kou, 1 Jonathan M. Haldeman, 1 Michelle Arlotto, 1 Phillip J. White, 1,4,5 Paul A. Grimsrud, 1,4 Inna … Hepatokines (Greek heapto-, liver; and -kinos, movement) are proteins produced by liver cells (hepatocytes) that are secreted into the circulation and function as hormones across the organism. Research is mostly focused on hepatokines that play a role in the regulation of metabolic diseases such as diabetes and fatty liver and include: Adropin, ANGPTL4, Fetuin-A, Fetuin-B, FGF-21, Hepassocin, LECT2, RBP4,Selenoprotein P, Sex hormone-binding globulin.
Hepatokine
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Web1 day ago · This hepatokine is secreted by the liver and acts locally, in peripheral tissues and in the brain to regulate food preference and energy expenditure (discussed further later) 87,88,89. WebNational Center for Biotechnology Information
WebJul 7, 2014 · FGF21 as a hepatokine, adipokine, and myokine in metabolism and diseases. Fibroblast growth factor (FGF) family members are mostly secreted as signaling proteins with diverse functions in development and metabolism. FGF21 is a unique FGF with metabolic, but not proliferative activities. WebSep 13, 2024 · Here, a novel hepatokine, pregnancy zone protein (PZP) is identified, which has significant induction during the refeeding stage of IF. Further, loss of function studies and protein therapeutic experiment in mice revealed that PZP promotes diet-induced thermogenesis through activating brown adipose tissue (BAT). Mechanistically, …
http://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.04.025 WebJun 29, 2024 · Hepatitis A Vaccination. Pronounced (hep-ah-TY-tiss) Hepatitis A is a liver disease caused by the hepatitis A virus (HAV). Hepatitis A can affect anyone. …
WebJan 12, 2024 · It remains unclear how hepatic steatosis links to inflammation. Leukocyte cell-derived chemotaxin 2 (LECT2) is a hepatokine that senses fat in the liver and is upregulated prior to weight gain.
WebDec 3, 2024 · Fgf21, another well-known hepatokine, is also an important thermogenic regulator but showed an opposite response to fasting as compared with Manf in the liver (Hondares et al., 2010). The hepatic and circulating levels of Fgf21 in mice are markedly up-regulated upon fasting and are suppressed by refeeding (Inagaki et al., 2007). Fgf21 can … legendary eagle ajWebIn conclusion, the hepatokine FGF-21 seems to play a role in the physiology of lipid metabolism, which renders it an appealing candidate for the treatment of some patients with NASH. There are favoring experimental and clinical results in phase 2 clinical trials. These have led to Phase 3 clinical trials, whose results may clarify whether FGF ... legendary eagle csgo rankWebIn this perspective, Stefan et al. address the dysregulation of hepatokines in people with NAFLD. The authors discuss the pathophysiological role of hepatokine-related organ crosstalk in the development of cardiometabolic disorders. Finally, the authors propose how levels of major hepatokines and adipokines may be used for pathomechanism-based … legendary eagleWebJul 14, 2024 · A recent study identified MANF as a hepatokine induced by feeding and revealed its potential role in energy homeostasis and obesity . Circulating MANF levels … legendary eagle csgoWebIntermittent hypoxia (IH), one of the primary pathologies of sleep apnea syndrome (SAS), exposes cells throughout the body to repeated cycles of hypoxia/normoxia that result in oxidative stress and systemic inflammation. Since SAS is epidemiologically strongly correlated with type 2 diabetes/insulin resistance, obesity, hypertension, and … legendary eagle stickerWebApr 13, 2024 · In this study, we utilized REnal Gluconeogenesis Analytical Leads (REGAL), a liquid chromatography-mass spectrometry/mass spectrometry-based stable isotope tracer method that we developed to show that in conditions of metabolic stress, the fasting hepatokine fibroblast growth factor-21 (FGF-21) coordinates a liver-brain-kidney axis to … legendary eagle master stickerWebMay 20, 2024 · Importantly, our data provide evidence that sFNDC4 acts as a hepatokine, as we observed that lowering of liver FNDC4 mRNA led to corresponding lowering of the sFNDC4-circulating levels in mice. legendary duelist synchro storm tcg